Report Summary

A Single-Dose 90 Day Biodistribution Study of Viral Test Article NP2 Administered Subcutaneously in BALB/C Mice

Study Summary

Overall Study Design 
The objective of this study was to evaluate the biodistribution of recombinant viral test article NP2 following a single 
subcutaneous injection in BALBc mice The test article was NP2 a replication-defective herpes simplex virus-based viral 
vector engineered to express human preproenkephalin The study consisted of two groups which were dosed with either 
control PBS or test article Mice 10 animalssextime point were then sacrificed at 1 7 28 or 91 days after dose 
administration and blood and tissue samples were retained for analysis 

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